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A method for producing alcohol placebos.

S Glautier1, C Taylor, B Remington

  • 1Addiction Research Unit, National Addiction Centre, London, UK.

British Journal of Addiction
|February 1, 1992
PubMed
Summary
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Researchers developed a method to create placebo drinks indistinguishable from alcoholic beverages. Using sensory analysis and paired comparisons, they identified the most effective placebo formulations for research applications.

Area of Science:

  • Food Science
  • Beverage Science
  • Sensory Analysis

Background:

  • Placebo-controlled studies are crucial in evaluating the effects of alcoholic beverages.
  • Developing effective placebos that mimic alcoholic drinks is challenging due to complex sensory profiles.

Purpose of the Study:

  • To establish a systematic method for creating placebo drinks that are perceptually similar to alcoholic counterparts.
  • To identify specific placebo formulations that minimize sensory discrimination from real alcoholic drinks.

Main Methods:

  • A paired comparison methodology was employed, presenting participants with alcoholic drinks and various placebo versions.
  • Subjects rated the 'alcoholic strength' and 'sensory intensity' of placebos relative to alcoholic drinks.
  • Multivariate analysis was used to determine the placebo most difficult to distinguish from its alcoholic counterpart.

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Main Results:

  • Specific placebo formulations were identified as being highly similar to their corresponding alcoholic drinks.
  • The method successfully differentiated placebo versions based on sensory discrimination.
  • The most effective placebo was identified for each of the two distinct alcoholic drinks tested.

Conclusions:

  • A robust method for developing indistinguishable alcoholic drink placebos has been demonstrated.
  • This approach can be generalized to create placebos for various alcoholic beverages.
  • The identified placebos are suitable for use in research where sensory perception is critical.