Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lues maligna.

K M T Watson1, J M L White, J R Salisbury

  • 1Department of Dermatology, King's College Hospital, London, UK. karen@doctorwatson.freeserve.co.uk

Clinical and Experimental Dermatology
|November 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of jaundice in advanced hepatocellular carcinoma - a sub-Saharan perspective.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2024
Same author

Occupational contact urticaria to cannabis sativa.

Occupational medicine (Oxford, England)·2022
Same author

The WHO ICD-11 Classification of Dermatological Diseases: a new comprehensive online skin disease taxonomy designed by and for dermatologists.

The British journal of dermatology·2021
Same author

A papular eruption on the elbows in a patient with rheumatoid arthritis.

Clinical and experimental dermatology·2021
Same author

The chameleon rash: a review of the polyphenotypic dermatoses of dermatomyositis.

Clinical and experimental dermatology·2021
Same author

The clinical and histopathological spectrum of neutrophilic inflammatory disease encountered in the setting of myelodysplastic syndrome.

Clinical and experimental dermatology·2021
Same journal

Real-World Outcomes of Stapokibart-Based Combination Therapy for Bullous Pemphigoid: A Single-Center Retrospective Cohort.

Clinical and experimental dermatology·2026
Same journal

A second case of recessive mosaicism in ABCA12 causing a congenital unilateral epidermal nevus.

Clinical and experimental dermatology·2026
Same journal

Dermatopathology.

Clinical and experimental dermatology·2026
Same journal

Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male.

Clinical and experimental dermatology·2026
Same journal

Shuddering Attacks in an Infant Treated with Atenolol for Infantile Hemangioma: A Previously Unreported Adverse Effect.

Clinical and experimental dermatology·2026
Same journal

Male genital fixed drug eruption: a systematic review.

Clinical and experimental dermatology·2026
See all related articles

Syphilis is increasing in the UK. A rare, severe secondary syphilis case (lues maligna) in an HIV-negative woman showed a false-negative rapid plasmin reagin test due to the prozone phenomenon.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Immunology

Background:

  • Syphilis incidence is rising globally, with a notable increase in the UK.
  • Secondary syphilis can manifest in severe forms, even in HIV-negative individuals.
  • Understanding diagnostic challenges is crucial for timely treatment.

Observation:

  • A case study of a Caucasian, HIV-negative woman presenting with secondary syphilis.
  • The patient exhibited a rare manifestation known as lues maligna.
  • Diagnostic serological tests revealed a complex pattern.

Findings:

  • The rapid plasmin reagin (RPR) test was negative, indicating a potential diagnostic challenge.
  • The Venereal Disease Research Laboratory (VDRL) test and Treponema pallidum haemagglutination assay were positive.

Related Experiment Videos

  • This discrepancy suggests the presence of the prozone phenomenon.

    • Implications:

    • The prozone phenomenon can lead to false-negative results in syphilis screening, delaying diagnosis.
    • Lues maligna, though rare, highlights the diverse and severe presentations of secondary syphilis.
    • Clinicians should maintain a high index of suspicion for syphilis, especially with atypical serological results.