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Making the right choice--long-range chromosomal interactions in development.

James R Broach1

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08558, USA. jbroach@molbio.princeton.edu

Cell
|November 20, 2004
PubMed
Summary
This summary is machine-generated.

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Schizosaccharomyces pombe switches mating types by interacting with silent DNA loci. A protein complex spreads across mating-type loci, marking the correct donor for switching.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Schizosaccharomyces pombe exhibits a unique ability to switch mating types each generation.
  • This mating type switching involves the expressor locus interacting with silent donor loci.

Purpose of the Study:

  • To elucidate the mechanism by which Schizosaccharomyces pombe selects the appropriate silent donor locus for mating type switching.
  • To understand the role of protein complexes and heterochromatin in this selection process.

Main Methods:

  • Investigated the interaction between the mating-type expressor locus and silent donor loci.
  • Analyzed the role of mating-type dependent and heterochromatin-dependent spreading of protein complexes.

Main Results:

Related Experiment Videos

  • Demonstrated that a protein complex is involved in marking the correct donor locus.
  • Showed that the spreading of this complex is dependent on mating-type and heterochromatin.
  • This complex facilitates the selection of the appropriate donor locus for mating type switching.

Conclusions:

  • The selection of the donor locus in Schizosaccharomyces pombe is mediated by the mating-type and heterochromatin-dependent spreading of a specific protein complex.
  • This mechanism ensures accurate and timely mating type switching in this fission yeast.