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Published on: October 27, 2020
Expression of cdc25A and cdc25B phosphatase in breast carcinoma
Yasuhiro Ito1, Hiroshi Yoshida, Takashi Uruno
1Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan. ito01@kuma-h.or.jp.
Background:
Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells. In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance.
Methods:
We immunohistochemically examined cdc25B and cdc25A expression in 46 cases of breast carcinoma.
Results:
Cdc25B and cdc25A were negative or only equivocally expressed in glandular epithelial cells. In breast carcinoma, 56.5% of cases had high levels of cdc25B expression. Interestingly, the expression of cdc25B was significantly lower in cases with biologically aggressive phenotypes. The cdc25A level was high in 69.6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters.
Conclusion:
These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression.
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