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Carcinoma in multinodular goitre.

K B Koh1, K W Chang

  • 1Department of Surgery, University Hospital, Lembah Pantai, Kuala Lumpur, Malaysia.

The British Journal of Surgery
|March 1, 1992
PubMed
Summary
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This study found that 7.5% of patients with multinodular goiter had incidental thyroid cancer, most commonly papillary carcinoma. Surgery for multinodular goiter is recommended for compressive symptoms, suspected malignancy, or cosmetic reasons.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Pathology

Background:

  • Multinodular goiter is a common thyroid condition.
  • Surgical intervention is often considered for various clinical reasons.
  • The incidence of occult malignancy in multinodular goiter requires precise determination.

Purpose of the Study:

  • To ascertain the prevalence of incidental thyroid carcinoma in patients undergoing surgery for multinodular goiter.
  • To identify the histological subtypes of incidental carcinomas.
  • To review the established indications for surgical management of multinodular goiter.

Main Methods:

  • A retrospective analysis was conducted on a cohort of 107 patients.
  • Patients included had undergone surgical operation for multinodular goiter.

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  • Histopathological examination of surgical specimens was performed to detect malignancy.

    • Main Results:

    • A total of 7.5% of the patients reviewed were found to have incidental carcinomas.
    • Papillary carcinoma was identified as the most frequent histological type among the incidental malignancies.
    • The study confirmed compressive symptoms, suspicion of malignancy, and cosmetic concerns as key indications for surgery.

    Conclusions:

    • A significant proportion of multinodular goiters harbor occult thyroid cancer.
    • Papillary thyroid cancer is the predominant incidental malignancy.
    • Surgical indications for multinodular goiter remain critical for patient management and diagnosis.