Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A physiological approach to motor disorders.

J W Lance, D J Burke, P D Neilson

    Electroencephalography and Clinical Neurophysiology. Supplement
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells.

    British journal of cancer·2014
    Same author

    The adsorption and desorption of ethanol ices from a model grain surface.

    The Journal of chemical physics·2008
    Same author

    New appendix criteria open for a broader concept of chronic migraine.

    Cephalalgia : an international journal of headache·2006
    Same author

    The International Classification of Headache Disorders, 2nd Edition (ICHD-II)--revision of criteria for 8.2 Medication-overuse headache.

    Cephalalgia : an international journal of headache·2005
    Same author

    Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cerevisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379.

    Molecular genetics and genomics : MGG·2004
    Same author

    Puffer fish poisoning: a potentially life-threatening condition.

    The Medical journal of Australia·2002

    Spasticity involves disinhibited spinal mechanisms, affecting stretch reflexes. Unlike Parkinson's disease, spasticity and cerebellar lesions disrupt normal stretch reflex pathways, leading to increased gain and reduced movement damping.

    Area of Science:

    • Neuroscience
    • Motor Control
    • Neurology

    Background:

    • Spasticity is characterized by disinhibited spinal cord mechanisms.
    • Stretch reflex responses depend on interactions between group Ia and group II afferent fibers.
    • Parkinson's disease reflex responses are not due to abnormal spinal mechanisms.

    Purpose of the Study:

    • To investigate the characteristics of the tonic stretch reflex in various neurological conditions.
    • To compare stretch reflex transmission in normal subjects, spasticity, Parkinson's disease, athetosis, and cerebellar disease.
    • To elucidate the role of long-loop pathways in motor control and spasticity.

    Main Methods:

    • Analysis of reflex responses to muscle stretch and shortening.
    • Assessment of the action tonic stretch reflex.

    Related Experiment Videos

  • Evaluation of reflex gain during voluntary contraction.

    • Main Results:

    • Reduced phase lead of the tonic stretch reflex in athetosis and cerebellar disease, impairing movement damping.
    • Absence of complex transmission characteristics in spasticity and cerebellar lesions, suggesting long-loop pathway interference.
    • High reflex loop gain in spasticity, regardless of contraction level, unlike normal subjects.

    Conclusions:

    • Spasticity involves altered spinal reflex mechanisms and impaired long-loop pathways.
    • Cerebellar disease and athetosis affect movement control through reduced reflex damping.
    • Understanding these reflex abnormalities is crucial for managing movement disorders.