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Updated: Aug 15, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
The evaluation of interactions between anaesthetic agent vapours and carrier gases by laser refractometry
J M Allison1, K P Birch, J G Crowder
1Ohmeda (a division of BOC Group Plc), Station Road, Steeton, West Yorkshire BD20 6RB, UK.
Abstract:
A measurement system and technique have been developed for the evaluation of interactions between anaesthetic agent vapours and carrier gases. The refractivities of mixtures of anaesthetic agent and carrier gas have been compared to values derived from the addition of the absolute refractivities of the individual components. These results show that there is no significant interaction between the anaesthetic agent and the carrier gas at the +/- 0.06% level of uncertainty. Results for the anaesthetic agents isoflurane, sevoflurane, enflurane, halothane, chloroform and desflurane and the carrier gases nitrogen, oxygen and dry air will be presented.
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