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Updated: Aug 7, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024
[Malignant laryngeal fibrous histiocytoma (MLFH). Report of two unusual cases]
F Ortiz Bish1, J Ruiz Clemente, H Galera Ruiz
1Servicio de ORL, Hospital Universitario Virgen Macarena, Sevilla. fortizbish@seorl.net
Abstract:
Laryngeal presentation of Malignat Fibrous Histiocytoma (MFH) is uncommon. It is more prevalent in elderly males. The most frequent form of laryngeal presentation is as subepithelial nodules, and its clinical behaviour is variable and unpredictable. Microscopically, it is a tumour with two well differentiated components: histiocitic and fibroblastic, with several different structural patterns that can make histologic diagnosis a difficult one. We present two cases of MFH of the larynx, and a review of the literature.

