Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Utilizing combination therapy to optimize melasma outcomes.

Marta I Rendon¹

¹Dermatology & Aesthetics Center, Boca Raton, FL 33486, USA. skincareresearch@cs.com

Journal of Drugs in Dermatology : JDD

|November 24, 2004

Summary

The most effective melasma treatment is a triple-combination cream (hydroquinone, tretinoin, fluocinolone acetonide). This therapy significantly improves melasma and patient quality of life within 8 weeks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience.

Journal of the American Academy of Dermatology·2018

Same author

Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.

Journal of drugs in dermatology : JDD·2018

Same author

Improving young physician membership and engagement in a dermatology physician organization: The Women's Dermatologic Society as a case example.

International journal of women's dermatology·2017

Same author

Clinical Evaluation of a 4% Hydroquinone + 1% Retinol Treatment Regimen for Improving Melasma and Photodamage in Fitzpatrick Skin Types III-VI.

Journal of drugs in dermatology : JDD·2017

Same author

Acne treatment patterns, expectations, and satisfaction among adult females of different races/ethnicities.

Clinical, cosmetic and investigational dermatology·2015

Same author

Long-term aesthetic outcomes with injectable poly-l-lactic acid: observations and practical recommendations based on clinical experience over 5 years.

Journal of cosmetic dermatology·2012

Area of Science:

Dermatology
Cosmetic Science

Background:

Melasma is a chronic, recurrent skin condition often undertreated due to limited effective therapies.
Historically, monotherapies like hydroquinone and kojic acid were used, but combination therapy is now standard.
Melasma is sometimes misperceived as a purely cosmetic issue, hindering proper diagnosis and treatment.

Purpose of the Study:

To evaluate the efficacy and safety of a triple-combination agent for melasma treatment.
To assess the long-term effectiveness and impact on quality of life for melasma patients.

Main Methods:

Clinical trials were conducted to assess the triple-combination cream (hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%).
A long-term study monitored efficacy and safety over 360 days.
Quality of life parameters were examined in patients using the combination cream.

Main Results:

The triple-combination cream achieved complete or near-complete melasma clearing in 8 weeks.
Long-term use (360 days) demonstrated sustained efficacy and safety.
Patients reported significant improvements in self-perception and quality of life.

Conclusions:

The triple-combination cream is the current gold standard for melasma therapy.
This treatment offers rapid and sustained improvement in melasma and significantly enhances patients' quality of life.
Adjunctive therapies, like chemical peels, may further enhance treatment outcomes when combined with the triple-combination cream.

Related Experiment Videos