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Related Experiment Videos

[Ototoxicity-related dysequilibrium].

Ph Lheureux1, A Penaloza

  • 1Service d'Accueil des Urgences, Unité de Toxicologie Aiguë, Hôpital Erasme, ULB, Bruxelles.

Journal De Pharmacie De Belgique
|November 24, 2004
PubMed
Summary
This summary is machine-generated.

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Ototoxic drugs can damage the inner ear or cranial nerve, causing hearing loss and equilibrium problems. Risk factors include kidney failure and age, necessitating careful monitoring for prevention.

Area of Science:

  • Oto-neuroscience
  • Pharmacology
  • Toxicology

Context:

  • Dizziness and equilibrium disturbances can stem from central nervous system (CNS) dysfunction or sensory input impairment.
  • Certain medications can induce hypotension upon positional changes.
  • This review focuses on drugs with true ototoxic properties, capable of damaging the inner ear or the vestibulocochlear nerve (cranial nerve VIII).

Purpose:

  • To review medications with known ototoxic properties.
  • To identify predisposing factors for ototoxicity.
  • To discuss preventative strategies for managing ototoxic drug-induced complications.

Summary:

  • Over 130 products are classified as potentially ototoxic, affecting hearing and/or balance.
  • Key ototoxic drug classes include aminoglycosides, macrolides, loop diuretics, antimalarials, and chemotherapeutics.

Related Experiment Videos

  • Predisposing factors for ototoxicity include renal failure, advanced age, polypharmacy with ototoxic agents, genetic predisposition, and pre-existing neurosensory deficits.

    • Impact:

    • Early identification of at-risk individuals is crucial for preventing severe, life-altering complications.
    • Therapeutic drug monitoring and vigilant cochleo-vestibular function assessment are vital, especially in high-risk patients.
    • Preventing ototoxicity preserves auditory and vestibular function, significantly improving patients' quality of life.