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Updated: Aug 20, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Blood platelet count and reactivity are associated with restenosis 6 months after coronary angioplasty

O Johansen1, M Brekke, I Seljeflot

  • 1Department of Cardiology, Ullevaal University Hospital, Oslo, Norway. odjo@uus.no

Scandinavian Cardiovascular Journal : SCJ
|November 24, 2004
PubMed

Insights

Elevated platelet-derived growth factor (PDGF) and beta-thromboglobulin (BTG) in aortic blood after percutaneous transluminal coronary angioplasty (PTCA) indicate a higher risk of restenosis. This suggests platelets contribute to restenosis development.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Interventional Cardiology

Background:

  • Restenosis affects 40-50% of patients post-percutaneous transluminal coronary angioplasty (PTCA).
  • Platelet-derived growth factor (PDGF) is implicated in the pathogenesis of restenosis.

Purpose of the Study:

  • To measure plasma PDGF levels in the coronary circulation during PTCA.
  • To correlate PDGF levels with the development of post-PTCA restenosis.

Main Methods:

  • Simultaneous blood sampling from the aortic root and coronary sinus before and after PTCA in 26 patients.
  • Measurement of plasma PDGF, beta-thromboglobulin (BTG), and platelet counts.
  • Assessment of restenosis via quantitative coronary angiography at 6 months.

Main Results:

  • Patients who developed restenosis showed significant increases in aortic root PDGF and BTG post-PTCA compared to those without restenosis.
  • Higher platelet counts were observed in patients who developed restenosis.
  • Elevated PDGF and BTG in the aortic root post-PTCA were associated with 6-month restenosis.

Conclusions:

  • Increased plasma PDGF and BTG in the aortic root after PTCA serve as potential markers for 6-month restenosis.
  • These findings support the hypothesis that platelets play a role in the restenosis process.
  • Platelet activation markers may help identify patients at risk for restenosis after PTCA.
Abstract

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