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Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
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[Vertical transmission of HGV and outcome of the infected babies]

G Dal Molin1, P D'Agaro, C Biagi

  • 1Dipartimento di Scienze di Medicina Pubblica, UCO Igiene e Medicina Preventiva, Università degli Studi di Trieste, IRCCS Burlo Garofolo Trieste.

Annali Di Igiene : Medicina Preventiva E Di Comunita
|November 24, 2004
PubMed

To assess the risk of HGV mother-to-infant transmission and the clinical outcome of infected babies, we investigated 103 mother-infant couples and followed-up the infected children for 4-72 months. Twenty (19.4%) mothers were HGV-RNA positive and transmission occurred in ten (50%) babies; only one child acquired HGV and HCV infection. Maternal factors, such as history of intravenous drug use, HCV-RNA positivity, HIV coinfection, type of delivery and type of feeding were not related to HGV transmission. One HGV infected baby showed a mild hepatitis when he was also infected by Cytomegalovirus. Two babies cleared HGV within the first year of life. The HGV transmission rate is elevated but HGV infection seems to be benign, at least in a short-term follow-up.

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