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Updated: Aug 20, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
[Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents
Silvio Aime1, Luisella Calabi, Camilla Cavallotti
1Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy. silvio.aime@unito.it
Abstract:
An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.
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Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

