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Related Experiment Videos

Pimozide in dermatologic practice: a comprehensive review.

Cynthia R Lorenzo1, John Koo

  • 1Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267-0592, USA. clorenzo@stanfordalumni.org

American Journal of Clinical Dermatology
|November 24, 2004
PubMed
Summary

Pimozide, an antipsychotic, shows efficacy beyond Tourette syndrome, particularly for dermatologic conditions like delusions of parasitosis and body dysmorphic disorder. This review highlights its therapeutic potential in dermatology practice.

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Area of Science:

  • Pharmacology
  • Dermatology
  • Psychiatry

Background:

  • Pimozide is an antipsychotic medication from the diphenylbutylpiperidine class.
  • While FDA-approved in the US for Tourette syndrome, it has broader international use for schizophrenia.
  • Off-label use in psychiatry and dermatology has increased over the last two decades.

Purpose of the Study:

  • To review the therapeutic applications of pimozide in dermatologic practice.
  • To inform physicians, particularly dermatologists, about pimozide's efficacy in various dermatologic conditions.
  • To provide a comprehensive overview of pimozide's uses in dermatology.

Main Methods:

  • A literature review was conducted.
  • Relevant studies and clinical information on pimozide were synthesized.

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  • The focus was on its application in dermatologic conditions.

    • Main Results:

    • Pimozide is highly effective for monosymptomatic hypochondriacal psychoses.
    • It is considered the primary treatment for delusions of parasitosis.
    • Efficacy has also been noted in body dysmorphic disorder, metastatic melanoma, trichotillomania, and neuralgias.

    Conclusions:

    • Pimozide offers significant therapeutic benefits for several dermatologic conditions.
    • Its use extends beyond its approved indications, especially in managing psychodermatologic disorders.
    • Dermatologists should consider pimozide for specific patient cases based on its established efficacy.