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Pharmacokinetics: philosophy of modeling

H Boxenbaum1

  • 1Marion Merrell Dow Inc., Cincinnati, Ohio 45215-6300.

Drug Metabolism Reviews
|January 1, 1992
PubMed

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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