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Updated: Aug 20, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci
Jong-Bae Kim1, Gyu-Sang Lee, Yun-Bong Kim
1Department of Biomedical Laboratory Science, College of Health Sciences, South Korea. kimjb@dragon.yonsei.ac.kr
Abstract:
The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC(90) of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.
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