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Updated: Aug 20, 2026

Growth-based Determination and Biochemical Confirmation of Genetic Requirements for Protein Degradation in Saccharomyces cerevisiae
Published on: February 16, 2015
Ubiquitin-dependent control of development in Saccharomyces cerevisiae
Jeffrey D Laney1, Mark Hochstrasser
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Box G-J2, Providence, Rhode Island 02912, USA. Jeffrey_laney@brown.edu
Abstract:
In response to external environmental stimuli and intrinsic developmental cues, yeast cells reset their gene expression programs and change phenotype. These switches in cellular state require the dismantling of an initial regulatory program, in addition to the induction of different sets of genes to specify the new cell phenotype. Recent experiments examining the role of protein degradation in these transitions have highlighted the importance of inactivating previously utilized regulators and have led to advances in our understanding of how cells change from one phenotypic state to another.
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