Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Statin Use Is Associated With Improved Survival But Not Progression-Free Outcomes in Patients With Unresectable Hepatocellular Carcinoma Receiving Atezolizumab-Bevacizumab.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same author

Direct and Functional Hazard Exposure of Urban Healthcare Systems Under Estimated Tsunami Inundation Zones: A Geographic Information System (GIS)-Based Cross-Boundary Analysis in Osaka City, Japan.

Cureus·2026
Same author

Limited indication of postoperative anticoagulation based on age reduces the incidence of deep venous thrombosis after anterior cruciate ligament reconstruction: A retrospective study.

Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology·2026
Same author

Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells.

EMBO reports·2026
Same author

Three Mycobacterium avium genotypes classified by 1.4-Mb genomic inversion and single-nucleotide variations are tightly linked to disease progression.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Rifaximin Improves Cognitive Performance and Reduces Cirrhosis-Related Adverse Events in Covert Hepatic Encephalopathy: A Randomized Controlled Trial.

Alimentary pharmacology & therapeutics·2026

Related Experiment Video

Updated: Jun 28, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Artificial metallo-DNA: a bio-inspired approach to metal array programming.

Mitsuhiko Shionoya1, Kentaro Tanaka

  • 1Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. shionoya@chem.s.u-tokyo.ac.jp

Current Opinion in Chemical Biology
|November 24, 2004
PubMed
Summary
This summary is machine-generated.

Researchers explore chemical methods to create self-assembled metal arrays within DNA using metal-mediated base pairing. This approach allows for programming molecular arrays with custom sequences for advanced applications.

More Related Videos

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Area of Science:

  • Biochemistry
  • Materials Science
  • Synthetic Chemistry

Background:

  • DNA's inherent structure allows for precise arrangement of functional units.
  • Modifying DNA bases offers novel ways to control molecular assembly.
  • Metal-mediated base pairing is a key strategy for DNA-based nanotechnology.

Purpose of the Study:

  • To review recent chemical advancements in creating self-assembled metal arrays within DNA.
  • To highlight the potential of alternative DNA bases for programming molecular structures.
  • To explore metal-mediated base pairing for designing functional DNA architectures.

Main Methods:

  • Focus on chemical synthesis strategies for functionalizing DNA.
  • Review of techniques for incorporating metal ions and creating metal-DNA complexes.
  • Analysis of self-assembly processes driven by metal-mediated base pairing.

Main Results:

  • Demonstration of DNA's capability to host ordered multi-arrays of functionalized units.
  • Successful integration of metal ions into DNA structures via modified base pairing.
  • Emergence of predictable self-assembly of metal arrays templated by DNA sequences.

Conclusions:

  • Chemical approaches enable the programming of DNA with metal arrays for novel functions.
  • Metal-mediated base pairing is a versatile tool for constructing sophisticated molecular architectures.
  • This strategy opens avenues for advanced DNA-based materials and nanodevices.