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Updated: Aug 20, 2026

Synthesis of Compound Giant Unilamellar Vesicles: A Biomimetic Model of Nucleate Cells
Published on: July 3, 2025
Replicating vesicles as models of primitive cell growth and division
Martin M Hanczyc1, Jack W Szostak
1Howard Hughes Medical Institute, Department of Molecular Biology, Mass. General Hospital, Boston, MA 02114, USA.
Abstract:
Primitive cells, lacking the complex bio-machinery present in modern cells, would have had to rely on the self-organizing properties of their components and on interactions with their environment to achieve basic cellular functions such as growth and division. Many bilayer-membrane vesicles, depending on their composition and environment, can exhibit complex morphological changes such as growth, fusion, fission, budding, internal vesicle assembly and vesicle-surface interactions. The rich dynamic properties of these vesicles provide interesting models of how primitive cellular replication might have occurred in response to purely physical and chemical forces.
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