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Latrotoxin-like properties of a protein from brain
V A Zhukareva1, Shatursky OYa, V K Lishko
1Palladin Institute of Biochemistry, Ukrainian Academy of Sciences, Kiev, USSR.
FEBS Letters
|April 6, 1992
Abstract:
In bovine brain cortex cytoplasm we have identified a soluble protein (L-protein) of M(r) approximately 90 kDa interacting with polyclonal antibodies to alpha-latrotoxin. The L-protein forms potential-dependent and cation-selective ion channels in BLM, which are blocked by Cd2+. The fusogenic activity of the L-protein was demonstrated on liposomes. We have arrived at the conclusion that the action mechanisms of the L-protein and alpha-latrotoxin are similar.