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Related Experiment Videos

Myofibromatosis: imaging characteristics.

Khaldoun Koujok1, Robert E Ruiz, Ramiro J Hernandez

  • 1Department of Radiology, CS Mott Children's Hospital, University of Michigan Health System, 1500 E. Medical Center Drive/F3503, Ann Arbor, MI 48109-0252, USA.

Pediatric Radiology
|November 24, 2004
PubMed
Summary

Infantile myofibromatosis imaging reveals varied appearances across ultrasound, CT, and MRI. Key findings include anechoic centers on ultrasound and peripheral enhancement on CT and MRI for these fibrous tumors.

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Area of Science:

  • Pediatric Radiology
  • Oncology
  • Medical Imaging

Background:

  • Infantile myofibromatosis is the most common fibrous tumor in infants, affecting skin, muscle, bone, and viscera.
  • It presents as solitary or multicentric forms, with or without visceral involvement.

Purpose of the Study:

  • To characterize the imaging features of extracranial infantile myofibromatosis.
  • To correlate imaging findings with histopathology for accurate diagnosis.

Main Methods:

  • Retrospective review of imaging studies (US, CT, MRI) in six infants (1 day-1 week old).
  • Detailed analysis of mass characteristics including signal intensity, enhancement patterns, and associated findings.

Main Results:

  • Ultrasound showed variable appearances, including purely anechoic centers with thick walls.

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  • CT revealed masses with lower/similar attenuation to muscle, often with peripheral enhancement.
  • MRI demonstrated low T1 signal, variable T2 signal (low or high center), and consistent peripheral enhancement post-gadolinium.

    • Conclusions:

    • Infantile myofibromatosis exhibits diverse imaging presentations.
    • Characteristic findings include anechoic centers on US, peripheral enhancement on CT/MRI, and potential bone involvement on CT.
    • Comprehensive imaging assessment is crucial for diagnosing extracranial infantile myofibromatosis.