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Updated: Aug 20, 2026

Isolation of Retinal Stem Cells from the Mouse Eye
Published on: September 11, 2010
Retinal stem cells and regeneration
Ala Moshiri1, Jennie Close, Thomas A Reh
1Neurobiology and Behavior Program, Department of Biological Structure, Center for Developmental Biology, Health Sciences Center, University of Washington, Seattle WA, USA.
Abstract:
The optic vesicle gives rise to several very different epithelial tissues, including the neural retina, the pigmented epithelium, the iris, the ciliary epithelium of the ciliary body and the optic stalk. Retinal regeneration can arise from several different cellular sources; in some species, the process involves interconversion, or transdifferentiation, among cells of the different tissue types. Therefore, prior to a discussion of retinal regeneration, we will briefly discuss current knowledge about the influence of signaling molecules in cell fate determination in ocular tissues. Next, we will detail the evidence for neurogenesis in the mature retina. Lastly, we will describe various types of regenerative phenomena that occur in the retina, from complete regeneration of functional retina in fish and amphibians, to the more limited neuronal production that occurs in avian and mammalian retinas.
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