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Related Experiment Videos

Quantitative cerebral perfusion using the PRESTO acquisition scheme.

Michael Pedersen1, Markus Klarhöfer, Søren Christensen

  • 1Department of Molecular and Functional Imaging (IMF) ERT CNRS, University Victor Segalen 2, Bordeaux, France. michael@mr.au.uk

Journal of Magnetic Resonance Imaging : JMRI
|November 24, 2004
PubMed
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The rapid principles of echo shifting with a train of observations (PRESTO) sequence is feasible for measuring cerebral hemodynamic parameters. PRESTO and echo-planar imaging (EPI) provide comparable quantitative perfusion results.

Area of Science:

  • Neuroimaging
  • Medical Physics

Background:

  • Cerebral hemodynamic parameters are crucial for understanding brain function and disease.
  • Accurate measurement of these parameters is essential for diagnosis and treatment monitoring.

Purpose of the Study:

  • To assess the feasibility of using the rapid principles of echo shifting with a train of observations (PRESTO) sequence for cerebral hemodynamic measurements.
  • To compare PRESTO with echo-planar imaging (EPI) for quantitative perfusion analysis.

Main Methods:

  • Simulations were conducted to analyze relaxation effects on resolution.
  • Experimental evaluation involved using PRESTO and EPI in healthy monkey brains.

Main Results:

  • Relaxation effects had minimal impact on signal amplitude in gray and white matter but significant impact in large vessels.

Related Experiment Videos

  • PRESTO showed a slight advantage over EPI in maintaining image resolution during bolus passage.
  • Both PRESTO and EPI yielded similar gray matter to white matter ratios for cerebral blood flow, cerebral blood volume, and mean transit time.

    • Conclusions:

    • The rapid principles of echo shifting with a train of observations (PRESTO) sequence is a feasible method for cerebral hemodynamic measurements.
    • PRESTO and EPI provide comparable quantitative perfusion parameters.