Ovarian function after uterine artery embolization and hysterectomy

Area of Science:

• Gynecology
• Interventional Radiology
• Reproductive Endocrinology

Background:

• Uterine fibroids (myomas) are common benign tumors affecting women of reproductive age.
• Symptomatic uterine myomas often necessitate treatment, with options including uterine artery embolization (UAE) and hysterectomy.
• The impact of these treatments on ovarian function is a critical consideration for women's reproductive health.

Purpose of the Study:

• To compare the effects of UAE and hysterectomy on ovarian function in premenopausal women.
• To assess changes in key hormonal markers of ovarian function (FSH, LH, E2) and ovarian volume post-treatment.
• To evaluate the efficacy of UAE in reducing uterine and myoma volume.

Main Methods:

• A prospective case-control study involving 84 premenopausal women with symptomatic uterine myomas.
• Patients underwent either UAE or hysterectomy.
• Hormonal levels (FSH, LH, E2) and transvaginal ultrasound measurements of uterine and myoma volume were assessed at baseline and at 3 and 6 months post-procedure.

Main Results:

• No significant differences in serum FSH levels were observed at 6 months post-UAE or post-hysterectomy compared to baseline.
• UAE resulted in a significant reduction in both uterine volume and dominant myoma volume at 6 months.
• Follow-up was completed by 48 patients after UAE and 13 after hysterectomy.

Conclusions:

• Uterine artery embolization is an effective treatment for reducing uterine and myoma volume.
• Neither UAE nor hysterectomy appears to negatively affect ovarian function, as indicated by day 3 FSH levels at 6 months post-treatment.