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Related Experiment Videos

Bloodstream infection complicating trauma.

Kevin Laupland1, Daniel B Gregson, Andrew W Kirkpatrick

  • 1Department of Critical Care Medicine, University of Calgary, Calgary, Alta.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|November 24, 2004
PubMed
Summary

Bloodstream infections (BSI) complicate major trauma in 1 in 25 patients, often occurring within the first week post-injury. Understanding BSI epidemiology is crucial for developing prevention and early treatment strategies.

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Area of Science:

  • Trauma Surgery
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Bloodstream infection (BSI) is a significant complication following major trauma.
  • Limited data exists on the incidence, risk factors, and outcomes of BSI in trauma patients.

Purpose of the Study:

  • To describe the occurrence, identify risk factors, and analyze outcomes of bloodstream infections in adult trauma patients.

Main Methods:

  • A cohort study linking regional trauma and microbiology databases.
  • Inclusion of adult trauma patients with Injury Severity Score (ISS) >= 12 over a 33-month period.

Main Results:

  • 4% of 1797 trauma patients developed BSI (71 patients, 77 episodes).
  • Higher ISS, ICU admission, and burns were independently associated with nosocomial BSI.

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  • BSI predicted increased in-hospital case fatality but was not an independent predictor of death.

    • Conclusions:

    • 1 in 25 major trauma cases experienced BSI, with over half occurring within the first week.
    • Epidemiological insights are vital for planning preventive and therapeutic interventions for BSI in trauma.