Pathogenesis of hepatocellular damage in chronic hepatitis C virus infection

Multiple factors may influence the host-virus interaction in patients infected with hepatitis C virus (HCV), and these may result in diverse disease presentations. In immune competent hosts, there is little evidence that direct cytopathicity plays a significant role in liver cell injury. However, when host conditions are altered to allow for unusually high levels of viral replication and viral protein expression (i.e., immunosuppression), HCV may induce direct hepatocellular damage. In most patients infected with HCV, a wide array of humoral and cell-mediated immune responses are triggered in response to HCV polypeptides; however, despite this host immune response, HCV infections usually persist. Furthermore, the host immune response, in its attempt to clear the virus from the liver, contributes to the hepatocellular damage (chronic hepatitis) seen in the majority of chronically infected patients.