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[Adhesion molecules. Their role in cardiovascular physiopathology]

Ariel Jaitovich1, Guillermo Jaim Etcheverry

  • 1Departamento de Biología Celular e Histología, Hospital de Clínicas José de San Martin, Facultad de Medicina, Universidad de Buenos Aires. arieljaitovich@hotmail.com

Medicina
|November 25, 2004
PubMed

Insights

Adhesion molecules, including integrins, selectins, and immunoglobulin superfamily members, are crucial in cardiovascular diseases. Targeting these molecules offers new therapeutic strategies for conditions like coronary artery disease.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cardiology

Context:

  • Adhesion molecules are vital cell receptors involved in cell traffic, interactions, and matrix contact.
  • Three key groups—integrins, selectins, and the immunoglobulin superfamily—are implicated in cardiovascular disease.
  • These molecules play roles in endothelial dysfunction, activation, and the pathogenesis of various heart conditions.

Purpose:

  • To review the functions of adhesion molecules in cardiovascular disease.
  • To explore the diagnostic and predictive value of adhesion molecule titers.
  • To discuss potential therapeutic strategies targeting adhesion molecules.

Summary:

  • Adhesion molecules mediate cell functions and are central to cardiovascular pathologies like coronary artery disease and myocarditis.
  • They are involved in endothelial dysfunction and are linked to the efficacy of statins.
  • Serologic titers of these molecules hold diagnostic and predictive significance.

Impact:

  • Understanding adhesion molecule function provides insights into cardiovascular disease mechanisms.
  • Identifying therapeutic targets among adhesion molecules may lead to novel treatments.
  • This review highlights the diagnostic and prognostic potential of adhesion molecule biomarkers.

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