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Updated: Aug 20, 2026

11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
MS and NMR investigation of bioactive quinazolones
Zoltán Szabó1, Erzsébet Osz, Tamás Lóránd
1Department of Biochemistry and Medical Chemistry, Faculty of Medicine, University of Pécs, PO Box 99, H-7601 Pécs, Hungary.
Journal of Biochemical and Biophysical Methods
|November 25, 2004
Abstract:
To prepare effective PARP [poly(ADP)-ribose)polymerase-1] inhibitors, starting from 2-mercapto-4(3H)-quinazolone (1), several S-alkyl derivatives--2-alkylsulfanyl-3H-quinazolin-4-ones (2-5, 7-9)--as well as an S-benzyl derivative (10) were prepared using a simple alkylation method. Some of them are known compounds. Their structure was studied thoroughly by MS and NMR methods.
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