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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
Diana Felnerova1, Jean-François Viret, Reinhard Glück
1Berna Biotech Ltd, Rehhagstrasse 79, CH-3018, Berne, Switzerland. diana.felnerova@bernabiotech.com
Abstract:
Lipid-based vesicles are a very promising approach to treat diseases such as cancer, chronic infections and auto-immunity. Modern drug encapsulation methods allow efficient packing of therapeutic substances inside liposomes, thereby reducing the systemic toxicity of the drugs. Specific targeting can enhance the therapeutic effect of the drugs through their accumulation at the diseased site. In the vaccine field, the integration of functional viral envelope proteins into liposomes has led to an antigen carrier and delivery system termed a virosome, a clinically proven vaccine platform for subunit vaccines with an excellent immunogenicity and tolerability profile.
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