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Updated: Aug 20, 2026

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
07:12

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells

Published on: September 9, 2021

The Jak-STAT pathway stimulated by interleukin 6

Curt M Horvath1

  • 1Department of Medicine, Evanston Northwestern Healthcare Research Institute, IL 60208, USA. curt.horvath@mssm.edu <curt.horvath@mssm.edu>

Science'S STKE : Signal Transduction Knowledge Environment
|November 25, 2004
PubMed

Insights

Signal transducer and activator of transcription 3 (STAT3) is crucial for development and immune functions. Interleukin 6 (IL6) activates STAT3, highlighting its role in inflammation.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Immunology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is broadly expressed.
  • STAT3 activation is triggered by growth signals and cytokines utilizing gp130 receptors.
  • STAT3 plays essential roles in embryonic development, stem cell biology, inflammation, and immune homeostasis.

Purpose of the Study:

  • To illustrate the activation pathway of STAT3.
  • To demonstrate the role of Interleukin 6 (IL6) in STAT3 activation.
  • To highlight STAT3's involvement in inflammatory processes.

Main Methods:

  • The study utilized an animation to visualize molecular processes.
  • The animation depicts the signaling cascade initiated by Interleukin 6 (IL6).

Main Results:

  • The animation visually represents the activation of STAT3.
  • The process shown involves the cytokine Interleukin 6 (IL6) binding to its receptor.
  • This leads to the activation of STAT3, a key signaling molecule.

Conclusions:

  • STAT3 is a critical signaling pathway activated by cytokines like IL6.
  • The activation of STAT3 is integral to inflammatory responses.
  • Understanding STAT3 activation is key to comprehending immune regulation and development.

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