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Peripheral arterial disease, diabetes, and mortality
Cynthia L Leibson1, Jeanine E Ransom, Wayne Olson
1Department of Health Sciences Research, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. leibson@mayo.edu
Diabetes Care
|November 25, 2004
Summary
Individuals with diabetes and peripheral arterial disease (PAD) face significantly higher mortality risks. PAD progression further increases death risk, especially in diabetic patients, highlighting the need for PAD monitoring in diabetes care.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Epidemiology
Background:
- Peripheral arterial disease (PAD) and diabetes mellitus are significant risk factors for cardiovascular morbidity and mortality.
- The combined impact of diabetes and PAD on mortality risk requires further investigation.
- Understanding PAD progression in diabetic patients is crucial for risk stratification.
Purpose of the Study:
- To estimate the mortality risk for individuals with both diabetes and PAD compared to those with either condition alone.
- To assess the association between PAD progression and mortality in individuals with diabetes and/or PAD.
Main Methods:
- A longitudinal cohort study in Rochester, Minnesota, identified residents aged 50-70 with prior PAD and/or diabetes diagnoses.
- Participants underwent baseline examinations and assessments for PAD progression at 2 and 4 years.
- Vital status was followed through December 1999.
Main Results:
- Individuals with both diabetes and PAD had a 2.2 times higher adjusted risk of death compared to those with PAD alone.
- PAD progression was associated with increased subsequent mortality, particularly in individuals with diabetes.
- Among diabetic patients with PAD progression, 100% died by 1999, versus 62% without progression.
Conclusions:
- Diabetes is an independent risk factor for PAD and associated mortality.
- Early detection and vigilant monitoring of PAD in diabetic patients are critical for reducing mortality.
- PAD progression significantly elevates mortality risk in diabetic individuals.