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Updated: Jul 21, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Selective loss of regulatory T cells in thymomas
Philipp Ströbel1, Andreas Rosenwald, Niklas Beyersdorf
1Institute of Pathology, University of Würzburg, Würzburg, Germany. philipp.stroebel@mail.uni-wuerzberg.de
Abstract:
Myasthenia gravis (MG) is the prime autoimmune manifestation of thymomas. We investigated the generation of T cells with a regulatory phenotype (T(R)) in thymomas with and without associated MG. In patients with MG(+) thymomas, maturation and export of T(R) cells but not of other T-cell subsets was significantly reduced. We conclude that imbalance between effector and regulatory T cells in thymomas may be involved in modulation of onset and/or severity of MG.
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