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[An experimental study on PLGA carrier for oral tissue engineered mucosa by subcutaneous implantation in rabbits]
Bing Qi1, Hong-wei Li, Yu-ming Wen
1Dept. of Oral Pathology, Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.
Objective:
To look for the best carrier for cultivating oral tissue engineered mucosa.
Methods:
A series of membrane of scaffold materials of polycleclide-co-plycoclide (PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1, 2, 3, 4 weeks respectively.
Results:
PLGA I , II, III degraded completely in rabbits after 2, 3, 4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGA I, II, III with surrounding tissues were normal and membranes had a good biocompatibility.
Conclusion:
The biodegrading rate of PLGA II is suitable for clinic practice. PLGA II was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.
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