Related Experiment Video
Updated: Aug 20, 2026
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
[Relationship between GATA-3 and IL-4 and IL-5 in patients with allergic rhinitis]
Hua-bin Li1, Den-min Han, Bing Zhou
1Department of Otorhinolaryngology, Jiangsu Province Hospital, Nanjjing 210029, China. noseli@tom.com
Objective:
To evaluate the relationship between GATA-3 and IL-4, IL-5 in patients with allergic rhinitis.
Methods:
The expression of GATA-3 was detected by immunochemistry and reverse transcriptase polymerase chain reaction (RT-PCR) in 23 patients with allergic rhinitis. IL-4, IL-5 were detected by enzyme-linked immunosorbent assay (ELISA).
Results:
The positive rate of GATA-3 was 86.9% (20/23) and the relative density ratio of GATA-3 and glyceraldehyde phosphate dehydrogenase (GAPDH) were 0.602 +/- 0.11 in patients with allergic rhinitis. The concentrations of IL-4, IL-5 were (135.5 +/- 66.4) pg/mg, (77.5 +/- 29.4) pg/mg, respectively. The expressions of GATA-3 and IL-4, IL-5 had positive relationship (r = 0.45 and 0.62, P < 0.05).
Conclusions:
GATA-3 contributed to the production of IL-4, IL-5 in patients with allergic rhinitis.
More Related Videos
06:08Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017