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Understanding the basis of resistance in the irksome Lys103Asn HIV-1 reverse transcriptase mutant through targeted
Fátima Rodríguez-Barrios1, Federico Gago
1Departamento de Farmacología, Universidad de Alcalá, E-28871 Alcalá de Henares, Madrid, Spain.
Abstract:
Results of targeted molecular dynamics simulations confirm the existence of a higher energy barrier for creation of the pocket where non-nucleoside reverse transcriptase inhibitors bind in the K103N mutant enzyme relative to wild-type.
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