Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aneuploidy and malignancy: an unsolved equation.

P Dey1

  • 1Pathology Department, Kuwait Cancer Control Centre, Shuwaikh, Kuwait. deypranab@hotmail.com

Journal of Clinical Pathology
|November 26, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compact metal nano-powder generator of 273 MW average power and synthesis of copper nano-powder.

The Review of scientific instruments·2024
Same author

Interfacial Tensions, Solubilities, and Transport Properties of the H<sub>2</sub>/H<sub>2</sub>O/NaCl System: A Molecular Simulation Study.

Journal of chemical and engineering data·2024
Same author

Modular electromagnetic railgun accelerator for high velocity impact studies.

The Review of scientific instruments·2022
Same author

First Report of 'Candidatus Phytoplasma solani' (16SrXII-A) Associated with Fox Nut (Euryale ferox Salisb.) Stolbur Disease in India.

Plant disease·2022
Same author

Image quality improvement for optical imaging interferometric microscopy.

Optics express·2021
Same author

First Report of <i>Papaya ring spot virus</i> (PRSV) Infecting Jute (<i>Corchorus olitorius</i>) in India.

Plant disease·2021
Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026
Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026
Same journal

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same journal

MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

Journal of clinical pathology·2026
Same journal

Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

Journal of clinical pathology·2026
Same journal

Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

Journal of clinical pathology·2026
See all related articles

Aneuploidy, an abnormal chromosome number, is common in tumors. This review explores how cell division errors and genetic instability contribute to aneuploidy and cancer progression.

Area of Science:

  • Oncology
  • Genetics
  • Cell Biology

Background:

  • Aneuploidy, the presence of an abnormal number of chromosomes, is frequently observed in malignant tumors.
  • The exact cause and role of aneuploidy in cancer development remain controversial.
  • Potential mechanisms include spindle checkpoint failure due to gene mutations and telomere dysfunction leading to failed cytokinesis.

Purpose of the Study:

  • To review the mechanisms underlying the development of aneuploidy.
  • To discuss the impact of aneuploidy on cancer progression.
  • To highlight evidence suggesting aneuploidy's active role in carcinogenesis.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Evidence from tumor-specific aneuploidy, preneoplastic conditions, and genetic instability in aneuploid cell lines was considered.

Related Experiment Videos

  • Focus on mutations in mitotic checkpoint genes was emphasized.

    • Main Results:

    • Spindle checkpoint failure and telomere dysfunction are proposed mechanisms for aneuploidy development.
    • Tumor-specific aneuploidy patterns and its presence in preneoplastic conditions suggest an early role.
    • Aneuploid cell lines exhibit increased genetic instability compared to diploid cells.

    Conclusions:

    • Aneuploidy is strongly implicated as a factor in carcinogenesis.
    • Understanding aneuploidy's mechanisms is crucial for cancer research.
    • Further investigation into the interplay between aneuploidy and cancer progression is warranted.