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Updated: Aug 20, 2026

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration
Published on: August 16, 2024
Virilisation in a case of transitional cell carcinoma of the ovary
L J Baldwin1, N Singh, A Tiltman
1Southampton General Hospital, Southampton University Hospital NHS Trust, Southampton, Hampshire SO16 6YD, UK. ljbaldwin@doctors.org.uk
Abstract:
A 52 year old woman presented with a five month history of emotional changes, voice changes, and of abdominal discomfort. Clinical, biochemical, and radiological examinations showed evidence of virilisation, raised testosterone, and a complex ovarian mass. Microscopy of the resection specimen showed the tumour to be a transitional cell carcinoma of the ovary with luteinisation and hyperplasia of the intervening stromal cells. This is a unique case of virilisation caused by transitional cell carcinoma of the ovary. Theories as to the origin of testosterone production in non-functioning ovarian tumours are discussed.
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