Related Experiment Video
Updated: Aug 20, 2026

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
Published on: March 20, 2026
[Undifferentiated, overlapping and mixed connective tissue diseases]
Mónica Ruiz Pombo1, Moisés Labrador Horrillo, Albert Selva O'Callaghan
1Servicio de Medicina Interna, Hospital General Vall d'Hebron, Barcelona, Spain.
Abstract:
Mixed connective tissue disease (MCTD), undifferentiated connective tissue disease and overlap syndromes are autoimmune systemic diseases that must be differentiated. Antibodies against the U1-ribonucleoprotein complex --spliceosome-- allows the diagnosis of mixed connective tissue disease. Links between the immunologic and clinical phenomena are emerging. Longitudinal studies of patients with MCTD highlight the impact of pulmonary hypertension and contribute to define the disease. Immunogenetic studies hold MCTD as an independent disease.
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