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Updated: Aug 20, 2026

Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry (CCMS)
Published on: December 20, 2010
Rapid analysis of total plasma homocysteine by tandem mass spectrometry
Karin Tuschl1, Olaf A Bodamer, Wolfgang Erwa
1Unit of Biochemical Genetics, University Children's Hospital of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Abstract:
Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.
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