Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrins and angiogenesis.

D G Stupack1, D A Cheresh

  • 1Department of Immunology, The Scripps Research Institute, La Jolla, California 9203, USA.

Current Topics in Developmental Biology
|November 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer.

Oncogenesis·2015
Same author

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.

Cell death & disease·2014
Same author

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.

Oncogene·2011
Same author

Oncogenic Ras/Src cooperativity in pancreatic neoplasia.

Oncogene·2011
Same author

Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules.

Oncogene·2009
Same author

Regulation of angiogenesis: apoptotic cues from the ECM.

Oncogene·2008
Same journal

Building a resilient ovarian reserve: Early soma-oocyte interactions.

Current topics in developmental biology·2026
Same journal

Role of macrophages in testis function.

Current topics in developmental biology·2026
Same journal

Role of retinoic acid in meiosis.

Current topics in developmental biology·2026
Same journal

Impact of cancer immunotherapies on oocyte health and ovarian function.

Current topics in developmental biology·2026
Same journal

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.

Current topics in developmental biology·2026
Same journal

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.

Current topics in developmental biology·2026
See all related articles

Integrins are key cell adhesion receptors that regulate blood vessel growth by controlling endothelial cell behavior. Changes in integrins or their ligands impact vascular development and repair.

Area of Science:

  • Molecular biology
  • Cell biology
  • Vascular biology

Background:

  • Blood vessel growth (angiogenesis) is tightly controlled by signaling pathways.
  • Endothelial cells involved in angiogenesis become proliferative and invasive but are more prone to apoptosis.
  • Integrins are crucial adhesion receptors mediating endothelial cell interactions with the extracellular matrix.

Purpose of the Study:

  • To investigate the role of integrins in regulating endothelial cell behavior during angiogenesis.
  • To understand how integrin function and ligand availability influence vascular cell dynamics.

Main Methods:

  • Analysis of molecular signaling pathways.
  • Study of endothelial cell proliferation, migration, and apoptosis.
  • Examination of integrin-ligand interactions and their impact on vascular cells.

Related Experiment Videos

Main Results:

  • Integrin-mediated interactions are critical for endothelial cell proliferation, migration, and survival.
  • Alterations in integrin repertoire or activity affect vascular cell regulation.
  • Changes in ligand availability and structure also modulate vascular cell behavior.

Conclusions:

  • Integrins are essential regulators of angiogenesis.
  • Modulating integrin function and ligand properties offers potential for controlling vascular growth and repair.