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Published on: September 27, 2024

Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes

Eun Seok Kang1, Hae Jin Kim, Yoo Mee Kim

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. endohclee@yumc.yonsei.ac.kr

Diabetes Research and Clinical Practice
|November 27, 2004
PubMed

Insights

High sensitivity C-reactive protein (hsCRP) levels in type 2 diabetes patients correlate with cardiovascular disease risk factors and carotid intima-media thickness. This suggests hsCRP may help predict accelerated atherosclerosis in this population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • High sensitivity C-reactive protein (hsCRP) is a sensitive marker for cardiovascular disease risk.
  • Type 2 diabetes patients often exhibit elevated serum hsCRP levels compared to non-diabetic individuals.
  • Factors influencing hsCRP levels in type 2 diabetes require further investigation.

Purpose of the Study:

  • To evaluate the association between serum hsCRP levels and cardiovascular disease risk factors in type 2 diabetic subjects.
  • To determine the relationship between serum hsCRP levels and carotid intima-media thickness (IMT) in type 2 diabetes.

Main Methods:

  • 105 type 2 diabetes patients (excluding severe cardiovascular disease) underwent carotid ultrasonography for IMT assessment.
  • Serum hsCRP concentrations were measured in all participants.
  • Data analysis focused on correlations between hsCRP, IMT, and various risk factors.

Main Results:

  • Serum hsCRP levels showed significant correlations with carotid IMT (mean and maximal, left and right sides).
  • hsCRP also correlated with body mass index, waist circumference, waist-hip ratio, total cholesterol, triglycerides, and LDL cholesterol.
  • These findings indicate a link between inflammation, atherosclerosis, and metabolic factors in type 2 diabetes.

Conclusions:

  • Serum hsCRP levels are significantly correlated with carotid IMT in type 2 diabetic patients.
  • hsCRP is associated with multiple cardiovascular disease risk factors in this population.
  • Elevated hsCRP may serve as a predictor of accelerated atherosclerosis in individuals with type 2 diabetes.
Abstract

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