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Related Experiment Videos

Cough and asthma.

Ian D Pavord1

  • 1Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. ian.pavord@uhl-tr.nhs.uk

Pulmonary Pharmacology & Therapeutics
|November 27, 2004
PubMed
Summary
This summary is machine-generated.

Cough variant asthma and related syndromes cause chronic cough. Eosinophilic inflammation is common, but mast cell activation in airways may specifically drive cough, responding to corticosteroids and other treatments.

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Area of Science:

  • Pulmonology
  • Allergy and Immunology

Background:

  • Cough variant asthma, eosinophilic bronchitis, and atopic cough are frequent causes of chronic cough.
  • Diagnosis can be challenging, necessitating detailed investigation of airway inflammation and responsiveness.

Purpose of the Study:

  • To explore the underlying mechanisms of cough in these related conditions.
  • To investigate the role of mast cell activation in cough pathogenesis.

Main Methods:

  • Assessment of airway inflammation, specifically eosinophilic presence.
  • Evaluation of mast cell activation markers and products.

Main Results:

  • All studied cough syndromes exhibit eosinophilic airway inflammation, similar to non-cough asthma.

Related Experiment Videos

  • Evidence of activated mast cells and elevated mast cell products was specific to cough-associated conditions, suggesting a role in superficial airway pathogenesis.

    • Conclusions:

    • Mast cell degranulation in superficial airways may be key to cough pathogenesis in these syndromes.
    • Cough variant asthma is responsive to corticosteroids, leukotriene antagonists, and antihistamines.
    • Further research can elucidate the link between airway inflammation and dysfunction.