Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marginal zone B cell physiology and disease.

Thiago Lopes-Carvalho1, John F Kearney

  • 1Division of Clinical and Developmental Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Current Directions in Autoimmunity
|November 27, 2004
PubMed
Summary

Marginal zone (MZ) B cells are crucial for fighting infections and maintaining immune balance. Extracellular signals influence their development, function, and potential role in autoimmune diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human anti-glycan reactivity emerges from B cells utilizing private gene rearrangements that are affinity maturated in germinal centers.

Immunity·2026
Same author

Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients.

Immunity·2025
Same author

Defining the Features of Complement-Active IgM.

Journal of molecular biology·2025
Same author

Human Anti-Glycan Reactivity is Driven by the Selection of B cells Utilizing Private Antibody Gene Rearrangements that are Affinity Maturated in Germinal Centers.

bioRxiv : the preprint server for biology·2024
Same author

The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same author

Microbiota and B-1 B cell repertoire development in mice.

Current opinion in immunology·2024

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mature B lymphocytes are not a uniform group; distinct functional and developmental subsets exist.
  • Marginal zone (MZ) B cells are a key peripheral subset vital for responding to blood-borne infections, especially encapsulated bacteria.

Purpose of the Study:

  • To review extracellular signals impacting MZ B cell development, selection, and function.
  • To examine the potential role of MZ B cell repertoire, location, and interactions in autoimmune disease induction.

Main Methods:

  • Literature review of extracellular signals affecting MZ B cells.
  • Analysis of MZ B cell characteristics in relation to immunity and autoimmunity.

Main Results:

  • MZ B cells bridge innate and adaptive immunity through rapid activation and differentiation.

Related Experiment Videos

  • These cells contribute to host defense against encapsulated bacteria and play roles in homeostasis and tolerance.
  • Extracellular signals significantly influence MZ B cell biology.

    • Conclusions:

    • MZ B cells are critical for host defense and immune regulation.
    • Their repertoire, location, and cellular interactions are implicated in the development of autoimmune diseases.