Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiotensin-converting enzyme insertion-deletion polymorphism in primary open-angle glaucoma.

Mehtap Ozkur1, Ibrahim Erbagci, Kivanc Gungor

  • 1Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. aozkur@hotmail.com

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|November 27, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vascular characteristics of pediatric patients with familial Mediterranean fever: a study of optical coherence tomography angiography findings.

Japanese journal of ophthalmology·2025
Same author

Bioequivalence study of two formulations of lurasidone film coated tablets in healthy subjects under fed conditions.

Scientific reports·2025
Same author

Severe Psoriasiform Blepharitis Accompanying with Phthisis Bulbi.

Middle East African journal of ophthalmology·2025
Same author

Strongly polarized color conversion of isotropic colloidal quantum dots coupled to fano resonances.

Nanoscale horizons·2024
Same author

Evaluation of the relationship between FDG-PET hypometabolism and retinal layer thickness in patients with Alzheimer's disease.

Acta neurologica Belgica·2024
Same author

High-throughput screening of transient receptor potential (TRP) channels in pterygium.

International ophthalmology·2024

This study found no significant association between the angiotensin-converting enzyme (ACE) gene insertion-deletion (I/D) polymorphism and primary open-angle glaucoma (POAG). Further research is needed to confirm the ACE gene

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
  • The genetic factors contributing to POAG susceptibility are not fully understood.
  • The angiotensin-converting enzyme (ACE) gene has been implicated in various physiological processes, making it a candidate for investigation in glaucoma.

Purpose of the Study:

  • To investigate the potential association between the insertion-deletion (I/D) polymorphism in the ACE gene and POAG.
  • To determine if specific ACE genotypes or allele frequencies are more common in POAG patients compared to healthy controls.

Main Methods:

  • A case-control study was conducted with 104 POAG patients and 101 healthy controls.
  • Polymerase chain reaction (PCR) was employed to detect the I/D polymorphism in the ACE gene.

Related Experiment Videos

  • Genotype and allele frequencies were compared between the POAG and control groups.

    • Main Results:

    • No statistically significant differences were observed in the genotype distributions (DD, ID, II) between POAG patients and controls (p = 0.1).
    • Allele frequencies for the D and I alleles of the ACE gene also did not differ significantly between the two groups (p = 0.8).
    • The observed frequencies suggest that the ACE I/D polymorphism is not a major genetic risk factor for POAG in this study population.

    Conclusions:

    • The study did not find evidence supporting an association between the ACE I/D polymorphism and POAG.
    • Larger-scale studies involving diverse populations are recommended to definitively ascertain the role of the ACE gene in POAG pathogenesis.
    • Further research may explore other genetic variations within the ACE gene or interactions with environmental factors.