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Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa
Tetsuya Ando1, Naoki Kodama, Toshio Ishikawa
1Division of Psychosomatic Research, National Institute of Mental Health, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Chiba, Japan. ando@ncnp-k.go.jp
Psychiatric Genetics
|November 27, 2004
Summary
This study investigated if variations in UCP-2/3 genes are linked to anorexia nervosa (AN). Researchers found no significant differences in gene polymorphisms between AN patients and healthy individuals, suggesting these UCP-2/3 gene variations do not predispose individuals to AN.
Area of Science:
- Genetics
- Metabolism
- Psychiatry
Background:
- Energy expenditure abnormalities are noted in anorexia nervosa (AN).
- Uncoupling proteins (UCPs) are involved in energy metabolism and thermogenesis.
- Previous studies suggested a link between UCP-2/UCP-3 gene markers and AN.
Purpose of the Study:
- To investigate the association between UCP-2/UCP-3 gene polymorphisms and the predisposition to anorexia nervosa.
- To determine if specific UCP-2 (insertion/deletion, -866G/A) and UCP-3 (-55C/T) polymorphisms are related to AN susceptibility.
Main Methods:
- A case-control association analysis was conducted.
- The study included 106 female Japanese AN patients and 126 healthy female controls.
- Frequencies of UCP-2/UCP-3 gene polymorphisms were compared between the two groups.
Main Results:
- No significant differences were found in the frequencies of UCP-2/UCP-3 gene polymorphisms between AN sufferers and normal controls.
- The analysis did not reveal any association between the studied polymorphisms and AN.
Conclusions:
- The hypothesis that UCP-2/UCP-3 gene variations influence susceptibility to anorexia nervosa is not supported by this study.
- These specific UCP-2/3 gene polymorphisms do not appear to be a predisposing factor for AN in the studied Japanese population.