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Resistant hypertension in patients with chronic aortic dissection

H Eggebrecht1, A Schmermund, C von Birgelen

  • 1Department of Cardiology, West-German Heart Center Essen, University of Duisburg-Essen, Essen, Germany. holger.eggebrecht@uni-essen.de

Journal of Human Hypertension
|November 27, 2004
PubMed

Insights

Achieving strict blood pressure control in aortic dissection (AD) patients often requires multiple antihypertensive drugs. However, 40% experience resistant hypertension, particularly younger, obese individuals.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Hypertension Management

Background:

  • Strict blood pressure control is crucial for managing patients with aortic dissection (AD).
  • Achieving target blood pressure levels in AD patients can be challenging.

Purpose of the Study:

  • To evaluate antihypertensive medical therapy and blood pressure (BP) control in patients with chronic AD.
  • To identify factors associated with effective BP control versus resistant hypertension in AD.

Main Methods:

  • Retrospective chart review of 40 patients with chronic AD.
  • Analysis of clinical variables, serial BP measurements, and antihypertensive drug regimens.
  • Patients categorized into effective BP control (<135/80 mmHg) and resistant hypertension (≥135/80 mmHg on ≥3 drugs) groups.

Main Results:

  • Effective BP control was achieved in 60% of patients; 40% had resistant hypertension.
  • Resistant hypertension group required significantly more antihypertensive drugs (median 5 vs. 4).
  • Resistant hypertension patients were younger and had higher body mass index.

Conclusions:

  • Effective BP control in chronic AD is achievable but often necessitates multiple antihypertensive medications.
  • A significant subset of younger, obese AD patients exhibits resistant hypertension despite aggressive medical management.
  • Further research into optimal therapeutic strategies for resistant hypertension in AD is warranted.

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