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Related Experiment Videos

Asystole associated with cluster headache.

Izzet Erdinler1, Nazire Afsar, Arda Sanli

  • 1Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.

The Canadian Journal of Cardiology
|November 27, 2004
PubMed
Summary

Cluster headaches can rarely cause asystole (cardiac arrest) and syncope (fainting). Prophylactic methysergide maleate effectively resolved these symptoms, suggesting a parasympathetic link.

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Area of Science:

  • Neurology
  • Cardiology
  • Autonomic Nervous System

Background:

  • Cluster headaches are a primary headache disorder characterized by severe unilateral pain.
  • Autonomic symptoms like lacrimation and rhinorrhea are common during attacks.
  • Cardiac involvement in cluster headaches is exceptionally rare.

Observation:

  • A 43-year-old male patient experienced episodes of asystole and syncope.
  • These episodes were temporally associated with cluster headache attacks.
  • The patient's medical history was otherwise unremarkable.

Findings:

  • Prophylactic treatment with methysergide maleate completely eliminated the asystole and syncope episodes.
  • This suggests a direct link between cluster headache and cardiac asystole/syncope.

Related Experiment Videos

  • The mechanism may involve hyperactivity of the parasympathetic nervous system during cluster headache attacks.

    • Implications:

    • This case highlights a unique and potentially dangerous association between cluster headaches and cardiac events.
    • It underscores the importance of considering cardiac causes in patients with cluster headaches experiencing syncope.
    • Pharmacological management targeting the autonomic nervous system may be beneficial in select cases.