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Related Experiment Videos

Diffusing capacity for carbon monoxide in children with type 1 diabetes.

M P Villa1, M Montesano, M Barreto

  • 1Department of Paediatrics, Sant'Andrea Hospital, II Faculty of Medicine, University La Sapienza, Via di Grottarossa, 1035-1039, 00189 Rome, Italy. mariapia.villa@uniroma1.it

Diabetologia
|November 27, 2004
PubMed
Summary

Poor glycemic control in children with type 1 diabetes is linked to reduced lung diffusing capacity. This early lung dysfunction may indicate pulmonary microangiopathy, highlighting the need for tight metabolic management.

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Area of Science:

  • Pediatric Pulmonology
  • Diabetology
  • Cardiopulmonary Research

Background:

  • Limited data exist on lung function in pediatric diabetes.
  • Type 1 diabetes mellitus (T1DM) can affect multiple organ systems.

Purpose of the Study:

  • To investigate the association between pulmonary function variables and disease-related factors in children with T1DM.

Main Methods:

  • 39 children with T1DM and 30 healthy controls underwent spirometry, N2 washout, and single-breath carbon monoxide diffusing capacity (DLCO/VA) tests.
  • Glycemic control was assessed using HbA1c levels (≤8% good, >8% poor).

Main Results:

  • Children with poor glycemic control exhibited significantly lower DLCO/VA percentages compared to those with good control and healthy controls.

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  • DLCO/VA percentages negatively correlated with HbA1c levels (r=-0.39, p=0.013).
  • HbA1c levels were identified as the sole predictor of DLCO/VA in a multivariate regression analysis.

    • Conclusions:

    • Reduced lung diffusing capacity is an early finding in children with T1DM and is associated with poor metabolic control.
    • This may suggest pulmonary microangiopathy secondary to T1DM.
    • Alternative explanations for diffusion capacity changes related to oxygen-hemoglobin binding are also considered.