Related Experiment Videos
TRAIL induction by radiation in lymphoma patients
Jaya Unnithan1, Roger M Macklis
1Department of Radiation Oncology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Cancer Investigation
|November 30, 2004
Summary
Radiation therapy can induce Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), a protein that triggers cancer cell death. This induction may enhance radiation
Area of Science:
- Oncology
- Immunology
- Radiation Biology
Background:
- Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) induces apoptosis in cancer cells.
- TRAIL is a member of the Tumor Necrosis Factor cytokine family.
- TRAIL combined with radiation shows synergistic effects in vitro.
Purpose of the Study:
- To investigate the induction of TRAIL by irradiation in cancer cell lines.
- To evaluate TRAIL levels in patients undergoing radiation therapy for lymphoma.
- To explore the role of radiation-induced TRAIL in the abscopal and bystander effects.
Main Methods:
- Irradiation of cancer cell lines to assess TRAIL induction.
- Measurement of TRAIL levels in 17 lymphoma patients receiving radiation therapy.
- Analysis of TRAIL expression patterns in relation to clinical parameters.
Main Results:
- TRAIL is induced by irradiation in certain cell lines, starting around 2 hours post-irradiation.
- No specific TRAIL expression pattern correlated with clinical factors was observed in patients.
- A consistent individual TRAIL pattern was noted in one patient over time.
- TRAIL and interferons share gene expression patterns at interaction points.
Conclusions:
- Radiation-induced TRAIL may enhance the antineoplastic effects of ionizing radiation.
- Radiation-induced TRAIL changes might contribute to the abscopal and bystander effects in cancer therapy.
- TRAIL expression alterations reflect broader physiological pathway responses to ionizing radiation.