Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres
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Updated: Aug 20, 2026
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
Published on: April 12, 2015
Djalil Coowar1, Julien Bouissac, Mazen Hanbali
1Laboratoire de Chimie Organique des Substances Naturelles, UMR 7123 CNRS, Université Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg, France.
Abstract:
In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.
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